| Identification | Back Directory | [Name]
Cyclohexanepentanoic acid, β-[[[5-(2,6-dimethoxyphenyl)-1-(4-fluorophenyl)-1H-pyrazol-3-yl]carbonyl]amino]-, (βS)- | [CAS]
1965244-85-2 | [Synonyms]
APJ receptor agonist 6
Cyclohexanepentanoic acid, β-[[[5-(2,6-dimethoxyphenyl)-1-(4-fluorophenyl)-1H-pyrazol-3-yl]carbonyl]amino]-, (βS)- | [Molecular Formula]
C29H34FN3O5 | [MOL File]
1965244-85-2.mol | [Molecular Weight]
523.61 |
| Hazard Information | Back Directory | [Uses]
APJ receptor agonist 6 (compound 9) is a potent APJ (apelin receptor) agonist, with Ki of 1.3 μM. APJ receptor agonist 6 has EC50 values of 0.070 , 0.097, and 0.063 μM for calcium, cAMP, and β-arrestin, respectively[1]. | [References]
[1] Narayanan S, et al. Identification of potent pyrazole based APELIN receptor (APJ) agonists. Bioorg Med Chem. 2020 Feb 15;28(4):115237. DOI:10.1016/j.bmc.2019.115237 |
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