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ChemicalBook--->CAS DataBase List--->2010159-47-2

2010159-47-2

2010159-47-2 Structure

2010159-47-2 Structure
IdentificationBack Directory
[Name]

MZP-54
[CAS]

2010159-47-2
[Synonyms]

MZP-54
[Molecular Formula]

C55H66ClN7O9S
[MOL File]

2010159-47-2.mol
[Molecular Weight]

1036.68
Chemical PropertiesBack Directory
[Boiling point ]

1219.3±65.0 °C(Predicted)
[density ]

1.275±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

Ethanol : 50 mg/mL (48.23 mM)
[form ]

Solid
[pka]

13.54±0.46(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

MZP-54 is a PROTAC connected by ligands for von Hippel-Lindau and BRD3/4, with a Kd of 4 nM for Brd4BD2.
[IC 50]

VHL; BRD4 BD2: 4 nM (Kd)
[storage]

Store at -20°C
[References]

[1] Chan KH, et al. Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds. J Med Chem. 2018 Jan 25;61(2):504-513. DOI:10.1021/acs.jmedchem.6b01912
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