天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

ChemicalBook--->CAS DataBase List--->201653-76-1

201653-76-1

201653-76-1 Structure

201653-76-1 Structure
IdentificationBack Directory
[Name]

NAMI-A
[CAS]

201653-76-1
[Synonyms]

NAMI-A
NAMIA;NAMI A
NAMI-A >=98% ruthenium (Ru) basis (elemental analysis)
[Molecular Formula]

C8H16Cl4N4ORuS
[MDL Number]

MFCD31630816
[MOL File]

201653-76-1.mol
[Molecular Weight]

459.17
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[form ]

Solid
[color ]

Pink to red
[Water Solubility ]

Water : 8.28 mg/mL (18.07 mM)
Hazard InformationBack Directory
[Uses]

NAMI-A is a ruthenium-based drug characterised by the selective activity against tumour metastases, inhibits the adhesion and migration. In vitro: NAMI-A can significantly affect tumor cells with metastatic ability. The half lifetime of NAMI-A elimination from the lungs is longer than for liver, kidney, and primary tumor. NAMI-A bound to collagen is active on tumor cells as shown in vitro by an invasion test, using a modified Boyden chamber and Matrigel, and it inhibits the matrix metallo-proteinases MMP-2 and MMP-9 at micromolar concentrations. [1] The ruthenium drug NAMI-A inhibits the adhesion and migration of colorectal cancer cells. NAMI-A decreases α5β1 integrin expression and FAK auto-phosphorylation on Tyr 397. [2] In vivo: The reference for NAMI-A is 35 mg/kg/day. [1]
[Pharmaceutical Applications]

NAMI-A has shown activity in the treatment of metastatic cancer and has completed phase I clinical trials in the Netherlands. It has been shown that the complex is relatively nontoxic. Significantly higher doses than cisplatin (above 500 mg/m2/day) lead to side effects such as blisters on the extremities. Within the study, the ruthenium complex was administered intravenously over a period of 3 h in a 0.9% saline solution (pH~4) .
The NAMI-A is synthesised by reacting RuCl3?3H20 with HCl and DMSO (dimethylsulfoxide). This reaction results in the trans complex Imidazolium trans-imidazoledimethyl sulfoxide-tetrachlororuthenate(III) (NAMI-A) . It is interesting to note that Imidazolium trans-imidazoledimethyl sulfoxide-tetrachlororuthenate(III) is a paramagnetic compound and the complex is quickly hydrolysed in water. Initially, one chloride ligand is replaced by an aquo ligand, but the DMSO ligand is quickly replaced as well. As previously mentioned, it has been suggested that the complex is activated by bio-reduction of the Ru(III) centre to Ru(II) in the hypoxic environment of cancer cells. There is not much knowledge at present about the biological target for Imidazolium trans-imidazoledimethyl sulfoxide-tetrachlororuthenate(III). It is known that it interacts with the imidazoles of proteins and that the interaction with DNA is only weak, questioning DNA as a primary target for the ruthenium drug.
[Biological Activity]

NAMI-A is a potent antimetastatic drug in vivo th at is exhibits little cytotoxicity towards many cancer cell lines. Antimetastatic of NAMI-A is attributed to the formation of adducts with membrane and cytosolic proteins. Nevertheless NAMI-A induces potent and selective cytotoxic effects in several leukemia cell lines. NAMI-A exhibits low toxicity for host tissues.', 'NAMI-A is a ruthenium-based anticancer agent.
[References]

[1] Sava G et al. Dual Action of NAMI-A in inhibition of solid tumor metastasis: selective targeting of metastatic cells and binding to collagen. Clin Cancer Res. 2003 May;9(5):1898-905. PMID:12738748
[2] Pelillo C et al. Inhibition of adhesion, migration and of α5β1 integrin in the HCT-116 colorectal cancer cells treated with the ruthenium drug NAMI-A. J Inorg Biochem. 2016 Jul;160:225-35. DOI:10.1016/j.jinorgbio.2016.02.025
201653-76-1 suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354 , +17819995354
Website: www.targetmol.com/
Company Name: Aladdin Scientific
Tel:
Website: www.aladdinsci.com/
Company Name: Shanghai EFE Biological Technology Co., Ltd.  
Tel: 021-65675885 18964387627
Website: http://www.efebio.com
Company Name: Musechem  
Tel: +1-800-259-7612
Website: www.musechem.com
Company Name: ChemeGen(Shanghai) Biotechnology Co.,Ltd.  
Tel: 18818260767
Website: http://www.chemegen.com
Company Name: Absin Bioscience Inc.  
Tel: 021-38015121 18438616290
Website: www.absin.cn/
Company Name: Shanghai hongqu biomedical technology co. LTD  
Tel: 88888888888
Website: www.approvedhomemanagement.com/ShowSupplierProductsList873228/0_EN.htm
Company Name: Energy Chemical  
Tel: 021-58432009 400-005-6266
Website: http://www.energy-chemical.com
Company Name: Beijing Jin Ming Biotechnology Co., Ltd.  
Tel: 010-60605840 15801484223;
Website: http://www.jm-bio.com/
Company Name: TargetMol Chemicals Inc.  
Tel: 4008200310
Website: https://www.targetmol.cn/
Company Name: Shanghai Maclean Biochemical Technology Co., LTD  
Tel: 021-50706066 15221275939
Website: www.macklin.cn/
Company Name: Suzhou Meishi Biotechnology Co., Ltd.  
Tel: 1173954148q
Website: www.approvedhomemanagement.com/ShowSupplierProductsList1822805/0_EN.htm
Company Name: RD International Technology Co., Limited  
Tel: 18024082417
Website: www.ruidiresearch.com
Company Name: Sangon Biotech (Shanghai) Co.,Ltd.  
Tel: 400-821-026
Website: www.sangon.com
Company Name: Merck KGaA  
Tel: 21-20338288
Website: www.sigmaaldrich.cn
Company Name: Biosynth Biological Technology (Suzhou) Co Ltd  
Tel: 51288865780
Website: www.biosynth.com
Company Name: Adooq Bioscience LLC  
Tel: 400-025-6535
Website: http://www.adooq.cn
Company Name: Absin Bioscience Inc.  
Tel: 021-38015121-8802
Website: http://www.absin.cn
Tags:201653-76-1 Related Product Information

  • HomePage | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Privacy | Terms | About Us
  • All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
    According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.
  • Copyright © 2023 ChemicalBook All rights reserved.