| Identification | Back Directory | [Name]
8-Quinolinol, 7-[(R)-[(4-methyl-2-pyrimidinyl)amino][4-(trifluoromethyl)phenyl]methyl]- | [CAS]
2022949-46-6 | [Synonyms]
Q134R
8-Quinolinol, 7-[(R)-[(4-methyl-2-pyrimidinyl)amino][4-(trifluoromethyl)phenyl]methyl]- | [Molecular Formula]
C22H17F3N4O | [MDL Number]
MFCD34567744 | [MOL File]
2022949-46-6.mol | [Molecular Weight]
410.39 |
| Chemical Properties | Back Directory | [Boiling point ]
607.9±65.0 °C(Predicted) | [density ]
1.389±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
4.25±0.50(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Q134R, a neuroprotective hydroxyquinoline derivative that suppresses nuclear factor of activated T cell (NFAT) signaling. Q134R can across blood-brain barrier. Q134R has the potential for Alzheimer's disease (AD) and aging-related disorders research[1]. | [Biological Activity]
Q134R, a neuroprotective hydroxyquinoline derivative that suppresses nuclear factor of activated T cell (NFAT) signaling. Q134R can across blood-brain barrier. Q134R has the potential for Alzheimer’s disease (AD) and aging-related disorders research[1].
Q134R (1-10 μM) suppresses NFAT signaling, without inhibiting calcineurin activity. Q134R partially inhibits NFAT activity in primary rat astrocytes, but does not prevent calcineurin-mediated dephosphorylation of a non-NFAT target, either in vivo, or in vitro[1].
Q134R (4 mg/kg; orally gavage; twice per day; for 7 days) treatment improves cognitive function in rodent models of AD‐like pathology[1]. | [in vivo]
Q134R (4 mg/kg; orally gavage; twice per day; for 7 days) treatment improves cognitive function in rodent models of AD‐like pathology[1]. | Animal Model: | APP/PS1 mice (12-month-old) injected with oligomeric Aβ (oAβ) peptides[1] | | Dosage: | 4 mg/kg | | Administration: | Orally gavage; twice per day; for 7 days | | Result: | Led to improved Y maze performance. |
| [References]
[1]. Pradoldej Sompol, et al. Q134R: Small chemical compound with NFAT inhibitory properties improves behavioral performance and synapse function in mouse models of amyloid pathology. Aging Cell. 2021 Jul;20(7):e13416. |
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