| Identification | Back Directory | [Name]
(2S,3S,4R)-8-[[3-[2,6-dimethyl-4-(3-methylsulfonylpropoxy)phenyl]phenyl]methoxy]-9-azatricyclo[4.4.0.02,4]deca-1(10),6,8-triene-3-carboxylate | [CAS]
2056254-98-7 | [Synonyms]
MK-8666 Tris
MK-8666 tromethamine
(2S,3S,4R)-8-[[3-[2,6-dimethyl-4-(3-methylsulfonylpropoxy)phenyl]phenyl]methoxy]-9-azatricyclo[4.4.0.02,4]deca-1(10),6,8-triene-3-carboxylate | [Molecular Formula]
C33H42N2O9S | [MOL File]
2056254-98-7.mol | [Molecular Weight]
642.76 |
| Hazard Information | Back Directory | [Uses]
MK-8666 (tromethamine) is a GPR40 agonist. MK-8666 (tromethamine) can be used in the research of type II diabetes[1]. | [IC 50]
GRR40 | [References]
[1] Hyde AM, et al. Synthesis of the GPR40 Partial Agonist MK-8666 through a Kinetically Controlled Dynamic Enzymatic Ketone Reduction. Org Lett. 2016 Nov 18;18(22):5888-5891. DOI:10.1021/acs.orglett.6b02910 |
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