| Identification | Back Directory | [Name]
1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHO-L-SERINE SODIUM SALT | [CAS]
208757-51-1 | [Synonyms]
DLPS
12:0 PS
12:0 PS (SODIUM SALT)
1,2-dilauroyl-sn-glycero-3-phospho-L-serine
1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHO-L-SERINE SODIUM SALT
1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHO-L-SERINE (SODIUM SALT);12:0 PS
Sodium (S)-2-amino-3-((((R)-2,3-bis(dodecanoyloxy)propoxy)oxidophosphoryl)oxy)propanoate | [Molecular Formula]
C30H57NNaO10P | [MDL Number]
MFCD00077388 | [MOL File]
208757-51-1.mol | [Molecular Weight]
645.74 |
| Hazard Information | Back Directory | [Description]
DLPS, also known as 1,2-dilauroyl-sn-glycero-3-phospho-L-serine, is an anionic phospholipid with lauric acid tails (12:0) and contains a carboxylic acid (COOH) and amine (NH2) in their head group. It has been used in the preparation of lipid-mixing vesicles, liposome, or artificial membrane. Due to the medium size of fatty acid chain, DLPS is used to form thinner membranes/walls. | [Uses]
12:0 PS may be used:
- in the preparation of large unilamellar vesicles (LUVs)
- as a standard to spike replicas of extracted lipid droplets?and calibration curve generation for lipidomic analysis
- to study its effects on α-secretase activity
| [General Description]
Phosphatidylserine (PS), an aminophospholipid is negatively charged and accounts for 2–10% of total cellular lipid. It is located in the membrane leaflets. | [Biochem/physiol Actions]
Phosphatidylserine (PS) plays a key role in protein kinase C pathways. It also helps in confining the intracellular proteins to membrane leaflets of cytosol. |
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