| Identification | Back Directory | [Name]
10H,13H-Benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13-dione, 9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-, (9S)- (9CI) | [CAS]
210346-40-0 | [Synonyms]
Topoisomerase I inhibitor 8
10H,13H-Benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13-dione, 9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-, (9S)- (9CI) | [Molecular Formula]
C24H21FN2O4 | [MOL File]
210346-40-0.mol | [Molecular Weight]
420.43 |
| Chemical Properties | Back Directory | [Melting point ]
265 °C (decomp) | [Boiling point ]
807.3±65.0 °C(Predicted) | [density ]
1.50±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
11.20±0.20(Predicted) | [color ]
Light yellow to brown |
| Hazard Information | Back Directory | [Uses]
Topoisomerase I inhibitor 8 is a potent topoisomerase I inhibitor. Topoisomerase I inhibitor 8 is a hexacyclic analogue of camptothecin, and displays cytotoxic effect against tumor cells[1]. | [IC 50]
Topoisomerase I | [References]
[1] Sugimori M, et al. Synthesis and antitumor activity of ring A- and F-modified hexacyclic camptothecin analogues. J Med Chem. 1998 Jun 18;41(13):2308-18. DOI:10.1021/jm970765q |
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