| Identification | Back Directory | [Name]
1-((S)-2-AMINO-PROPYL)-1H-INDAZOL-6-OL | [CAS]
210580-75-9 | [Synonyms]
AL 34497
AL-34662
1-((S)-2-AMINO-PROPYL)-1H-INDAZOL-6-OL
1H-Indazol-6-ol, 1-[(2S)-2-aminopropyl]- | [Molecular Formula]
C10H13N3O | [MDL Number]
MFCD09031487 | [MOL File]
210580-75-9.mol | [Molecular Weight]
191.23 |
| Chemical Properties | Back Directory | [Melting point ]
170-172 °C(Solv: dichloromethane (75-09-2)) | [Boiling point ]
372.8±22.0 °C(Predicted) | [density ]
1.31±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
≤1mg/ml in ethanol;10mg/ml in DMSO;10mg/ml in dimethyl formamide | [form ]
crystalline solid | [pka]
9.30±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
AL-34662 is a selective 5-HT2A receptoragonist (IC50: 0.77 nM and 1.5 nM for rat and human 5-HT2 receptor). AL-34662 is also a weak α-1D adrenergic agonist activity (EC50:0.4 μM). AL-34662 is an ocular hypotensive agent[1][2]. | [Biological Activity]
al 34662 is a potent 5-ht2 receptor agonist.serotonin (5-hydroxytryptamine; 5-ht) is a major neurotransmitter in the central nervous system (cns) of mammals and has welldocumented physiological functions in numerous cells, tissues, and organs. | [in vitro]
al-34662 exhibited a high affinity for the rat and human 5-ht2 receptor and for cloned human 5-ht2a-c receptors. al-34662 stimulated phosphoinositide turnover in human ciliary muscle and in human trabecular meshwork cells. al-34662 also mobilized intracellular ca2+ in h-cm and h-tm cells, being a full agonist like 5-ht itself. al-34662's effects in the h-cm cells were potently antagonized by 5-ht2a-antagonist m-100907, but weakly by 5-ht2b-antagonist, 5-ht2b/c- antagonist and 5-ht2c antagonist. moreover, it was found that the (r)-enantiomer (al-34707) and the racemate (al-34497) were less potent and/or efficacious than al-34662 in all of these assays [1]. | [in vivo]
al-34662 caused relatively minimal ocular discomfort and hyperemia in rabbit and guinea pig eyes. it efficaciously lowered intraocular pressure in the conscious ocular hypertensive monkey eyes [1]. | [IC 50]
0.8-1.5 nm for rat and human 5-ht2 receptor | [storage]
Store at -20°C | [References]
[1] sharif na, mclaughlin ma, kelly cr. al-34662: a potent, selective, and efficacious ocular hypotensive serotonin-2 receptor agonist. j ocul pharmacol ther. 2007 feb;23(1):1-13. |
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