| Identification | Back Directory | [Name]
Imidazo[1,2-a]pyrazine, 8-[(2-fluorophenyl)methyl]-6-[5-(trifluoromethyl)-1H-1,2,4-triazol-3-yl]- | [CAS]
2201048-82-8 | [Synonyms]
CY6463
Zagociguat
Imidazo[1,2-a]pyrazine, 8-[(2-fluorophenyl)methyl]-6-[5-(trifluoromethyl)-1H-1,2,4-triazol-3-yl]- | [Molecular Formula]
C16H10F4N6 | [MOL File]
2201048-82-8.mol | [Molecular Weight]
362.28 |
| Chemical Properties | Back Directory | [density ]
1.59±0.1 g/cm3(Predicted) | [solubility ]
DMSO : 250 mg/mL (690.07 mM; Need ultrasonic) | [form ]
Solid | [pka]
5.69±0.40(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
Zagociguat is the stimulator of soluble guanylate cyclase. Zagociguat increases nitric oxide (NO) signaling leading to an increase in cyclic guanosine monophosphate production. Zagociguat has the potential for the research of noncentral nervous system (CNS) disorders[1]. | [References]
[1] Debra J. Wallace, et al. Accelerated Development of a Scalable Synthesis of CY6463, a CNS-Penetrant sGC Stimulator for the Treatment of Neurodegenerative Diseases. Org Process Res Dev. 2021;25(10):2288-2299. |
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