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ChemicalBook--->CAS DataBase List--->22112-89-6

22112-89-6

22112-89-6 Structure

22112-89-6 Structure
IdentificationBack Directory
[Name]

5,15-DIPHENYL-21H,23H-PORPHINE
[CAS]

22112-89-6
[Synonyms]

5,15-DPP
5,15-DIPHENYLPORPHINE
5,15-Diphenylporphyrin
5,15-Diphenylporphyrin>
5, 15-BIS-(PHENYL)PORPHYRINS
Stat3 Inhibitor VIII, 5,15-DPP
5,15-DIPHENYL-21H,23H-PORPHINE
21H,23H-Porphine, 5,15-diphenyl-
5,15-Bis-(phenyl)-21H,23H-porphyrins
10,20-diphenyl-21,22-dihydroporphyrin
STAT3 Inhibitor VIII, 5,15-DPP - CAS 22112-89-6 - Calbiochem
[Molecular Formula]

C32H22N4
[MDL Number]

MFCD08276335
[MOL File]

22112-89-6.mol
[Molecular Weight]

462.54
Chemical PropertiesBack Directory
[Melting point ]

>200℃
[Boiling point ]

912.3±65.0 °C(Predicted)
[density ]

1.285±0.06 g/cm3(Predicted)
[storage temp. ]

+2C to +8C
[solubility ]

≤2mg/ml in dimethyl formamide
[form ]

Deep blue to deep purple solid
[color ]

Red to Dark blue to Black
Questions And AnswerBack Directory
[Uses]

5,15-Diphenylporphyrin (cas# 22112-89-6) is a useful research chemical.
Safety DataBack Directory
[WGK Germany ]

3
[HS Code ]

2933.99.8290
[HazardClass ]

IRRITANT
Hazard InformationBack Directory
[Biological Activity]

5,15-diphenylporphyrin (5,15-dpp) is a selective stat3-sh2 antagonist [1].stat3 is constitutively activated in many human cancers. stat3 functions as a critical mediator of oncogenic signaling through transcriptional activation of genes encoding apoptosis inhibitors, cell-cycle regulators and inducers of angiogenesis [2]. aberrant stat3 activity has been associated with transforming mechanisms induced by oncogenic tyrosine kinases [1].
[in vitro]

5,15-dpp directly bound to stat3 and antagonized the function of stat3-sh2. 5,15-dpp selectively antagonized stat3-sh2 with an ic50 of 0.28 μm over the other sh2-containing proteins stat1 and grb2[1]. the estimated kd values for the 5,15-dpp binding to stat3 was 880 nm. treatment with 5,15-dpp suppressed the dna binding activity of stat3 in a concentration-dependent manner. 5,15-dpp poorly inhibited stat1 with an ic50 of 10 μm and showed no effect grb2 [1].
[References]

[1] uehara y, mochizuki m, matsuno k, et al. novel high-throughput screening system for identifying stat3–sh2 antagonists[j]. biochemical and biophysical research communications, 2009, 380(3): 627-631.
[2] jing n, tweardy d j. targeting stat3 in cancer therapy[j]. anti-cancer drugs, 2005, 16(6): 601-607.
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