| Identification | Back Directory | [Name]
Polymyxin B nonapeptide TFA | [CAS]
2220175-42-6 | [Synonyms]
Polymyxin B nonapeptide TFA | [Molecular Formula]
C45H75F3N14O13 | [MDL Number]
MFCD32708539 | [MOL File]
2220175-42-6.mol | [Molecular Weight]
1077.18 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C,protect from light | [form ]
Solid | [color ]
White to off-white | [Water Solubility ]
Water: 100 mg/mL (65.22 mM) |
| Hazard Information | Back Directory | [Uses]
Polymyxin B nonapeptide TFA is a cyclic peptide obtained from Polymyxin B by proteolytic removal of its terminal amino acyl residue. Polymyxin B nonapeptide TFA is less toxic, lacks bactericidal activity, and retains its ability to render gram-negative bacteria susceptible to several antibiotics by permeabilizing their outer membranes[1][2][3]. | [in vivo]
Polymyxin B nonapeptide TFA (1.5, 3.0 mg/kg intravenously for 29 days) does not exhibit neuromuscular blocking, neurotoxic, or nephrotoxic effects in rats as observed with polymyxin B sulfate[2].
| [References]
[1] Al-Marzooq F, et al. Discerning the role of polymyxin B nonapeptide in restoring the antibacterial activity of azithromycin against antibiotic-resistant Escherichia coli. Front Microbiol. 2022 Sep 21;13:998671. DOI:10.3389/fmicb.2022.998671
[2] Danner RL,et al. Purification, toxicity, and antiendotoxin activity of polymyxin B nonapeptide. Antimicrob Agents Chemother. 1989 Sep;33(9):1428-34. DOI:10.1128/AAC.33.9.1428
[3] Ofek I, et al. Antibacterial synergism of polymyxin B nonapeptide and hydrophobic antibiotics in experimental gram-negative infections in mice. Antimicrob Agents Chemother. 1994 Feb;38(2):374-7. DOI:10.1128/AAC.38.2.374 |
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