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ChemicalBook--->CAS DataBase List--->2220175-42-6

2220175-42-6

2220175-42-6 Structure

2220175-42-6 Structure
IdentificationBack Directory
[Name]

Polymyxin B nonapeptide TFA
[CAS]

2220175-42-6
[Synonyms]

Polymyxin B nonapeptide TFA
[Molecular Formula]

C45H75F3N14O13
[MDL Number]

MFCD32708539
[MOL File]

2220175-42-6.mol
[Molecular Weight]

1077.18
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C,protect from light
[form ]

Solid
[color ]

White to off-white
[Water Solubility ]

Water: 100 mg/mL (65.22 mM)
Hazard InformationBack Directory
[Uses]

Polymyxin B nonapeptide TFA is a cyclic peptide obtained from Polymyxin B by proteolytic removal of its terminal amino acyl residue. Polymyxin B nonapeptide TFA is less toxic, lacks bactericidal activity, and retains its ability to render gram-negative bacteria susceptible to several antibiotics by permeabilizing their outer membranes[1][2][3].
[in vivo]

Polymyxin B nonapeptide TFA (1.5, 3.0 mg/kg intravenously for 29 days) does not exhibit neuromuscular blocking, neurotoxic, or nephrotoxic effects in rats as observed with polymyxin B sulfate[2].

[References]

[1] Al-Marzooq F, et al. Discerning the role of polymyxin B nonapeptide in restoring the antibacterial activity of azithromycin against antibiotic-resistant Escherichia coli. Front Microbiol. 2022 Sep 21;13:998671. DOI:10.3389/fmicb.2022.998671
[2] Danner RL,et al. Purification, toxicity, and antiendotoxin activity of polymyxin B nonapeptide. Antimicrob Agents Chemother. 1989 Sep;33(9):1428-34. DOI:10.1128/AAC.33.9.1428
[3] Ofek I, et al. Antibacterial synergism of polymyxin B nonapeptide and hydrophobic antibiotics in experimental gram-negative infections in mice. Antimicrob Agents Chemother. 1994 Feb;38(2):374-7. DOI:10.1128/AAC.38.2.374
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