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ChemicalBook--->CAS DataBase List--->2229050-90-0

2229050-90-0

2229050-90-0 Structure

2229050-90-0 Structure
IdentificationBack Directory
[Name]

FLT3-IN-3
[CAS]

2229050-90-0
[Synonyms]

SAN50900
FLT3-IN-3
9H-Purine-2,6-diamine, N2-(trans-4-aminocyclohexyl)-9-cyclopentyl-N6-[4-(4-morpholinylmethyl)phenyl]-
inhibit,Fms like tyrosine kinase 3,FLT-3-IN-3,FLT3,CD135,Inhibitor,Cluster of differentiation antigen 135,FLT3IN3,FLT3 IN 3
[Molecular Formula]

C27H38N8O
[MDL Number]

MFCD31813658
[MOL File]

2229050-90-0.mol
[Molecular Weight]

490.64
Chemical PropertiesBack Directory
[Boiling point ]

717.6±70.0 °C(Predicted)
[density ]

1.42±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 15 mg/ml; PBS (pH 7.2): insol
[form ]

A solid
[pka]

10.42±0.70(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

FLT3-IN-3 is a potent FLT3 inhibitor with IC50s of 13 and 8 nM for FLT3 WT and FLT3 D835Y, respectively.
[in vivo]

A single dose of FLT3-IN-3 (Compound 7d; 10 mg/kg; i.p.) in mice with subcutaneous MV4-11 xenografts causes sustained inhibition of FLT3 and STAT5 phosphorylation over 48 hours[1].

Animal Model:Female athymic nu/nu mice with subcutaneously implanted MV4-11 xenografts[1]
Dosage:10 mg/kg
Administration:Intraperitoneal (i.p.) injection; 48 hours
Result:Effectively inhibited FLT3-ITD autophosphorylation in MV4-11 xenografts.
[storage]

Store at -20°C
[References]

[1] Gucky T, et al. Discovery of N2-(4-Amino-cyclohexyl)-9-cyclopentyl- N6-(4-morpholin-4-ylmethyl-phenyl)- 9H-purine-2,6-diamine as a Potent FLT3 Kinase Inhibitor for Acute Myeloid Leukemia with FLT3 Mutations. J Med Chem. 2018 May 10;61(9):3855-3869. DOI:10.1021/acs.jmedchem.7b01529
Spectrum DetailBack Directory
[Spectrum Detail]

FLT3-IN-3(2229050-90-0)1HNMR
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