| Identification | Back Directory | [Name]
Nutlin carboxylic acid | [CAS]
2249750-27-2 | [Synonyms]
MDM2 ligand 1
E3 ligase Ligand 16
Nutlin carboxylic acid
rel-2-(4-((4S,5R)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)-2-oxopiperazin-1-yl)acetic acid | [Molecular Formula]
C32H32Cl2N4O6 | [MDL Number]
MFCD32197285 | [MOL File]
2249750-27-2.mol | [Molecular Weight]
639.53 |
| Chemical Properties | Back Directory | [Boiling point ]
803.1±75.0 °C(Predicted) | [density ]
1.39±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
3.66±0.10(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Uses]
Nutlin carboxylic acid (MDM2 ligand 1) is the Nutlin 3-based MDM2 ligand. Nutlin carboxylic acid can be connected to the ligand for protein by a linker to form PROTAC[1]. | [IC 50]
MDM2 | [References]
[1] Hu Chunqi, et al. Dimer amide micromolecule PROTACs for inducing MDM2 to self-degrade E3 ubiquitin ligase. Patent CN108610333A. |
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