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ChemicalBook--->CAS DataBase List--->2258608-78-3

2258608-78-3

2258608-78-3 Structure

2258608-78-3 Structure
IdentificationBack Directory
[Name]

UCM-1306
[CAS]

2258608-78-3
[Synonyms]

UCM1036
UCM-1306
[Molecular Formula]

C14H14FNO2S
[MOL File]

2258608-78-3.mol
[Molecular Weight]

279.33
Chemical PropertiesBack Directory
[Boiling point ]

377.5±52.0 °C(Predicted)
[density ]

1.21±0.1 g/cm3(Predicted)
[form ]

Solid
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

UCM-1306 is a potent and orally active human dopamine D1 receptor allosteric modulator (PAM). UCM-1306 increases the endogenous dopamine (DA) maximal effect both in human and mouse D1 receptors. UCM-1306 is not only for improving motor symptoms but also for addressing the key comorbid cognitive impairment associated with long-term Parkinson’s disease (PD)[1].
[in vivo]

UCM-1306 (2-(Fluoromethoxy)-4'-(S-methylsulfonimidoyl)-1,1'-biphenyl; 5 mg/kg; p.o.; C57BL/6J mice) has good brain penetration and oral availability. Plasma concentration can be quantified for up to 8 h with Tmax at 0.5 h[1].
UCM-1306 (1 mg/kg; ip) enhances cocaine-induced hyperlocomotion in adult mice[1].
UCM-1306 (1 mg/kg; ip) helps consolidate long-term memory formation[1].

Animal Model:Adult C57BL/6J mice with cocaine-induced hyperactivity model[1]
Dosage:1 mg/kg; cocaine (20 mg/kg, sc)
Administration:Intraperitoneal injection
Result:Increased cocaine-induced hyperlocomotion, suggesting an in vivo potentiation of DA action at the D1R.
Animal Model:Adult C57BL/6J mice
Dosage:1 mg/kg
Administration:Intraperitoneal injection
Result:Increased memory trace in C57BL/6J mice.
[References]

[1] García-Cárceles J, et, al. 2-(Fluoromethoxy)-4'-(S-methanesulfonimidoyl)-1,1'-biphenyl (UCM-1306), an Orally Bioavailable Positive Allosteric Modulator of the Human Dopamine D1 Receptor for Parkinson's Disease. J Med Chem. 2022 Sep 22;65(18):12256-12272. DOI:10.1021/acs.jmedchem.2c00949
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