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ChemicalBook--->CAS DataBase List--->2267282-21-1

2267282-21-1

2267282-21-1 Structure

2267282-21-1 Structure
IdentificationBack Directory
[Name]

(S,R,S)-AHPC-PEG4-ALKYNE
[CAS]

2267282-21-1
[Synonyms]

(S,R,S)-AHPC-PEG4-ALKYNE
(2S,4R)-1-((S)-2-(tert-Butyl)-4-oxo-7,10,13,16-tetraoxa-3-azanonadec-18-ynoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
(2S,4R)-1-[(2S)-3,3-dimethyl-2-(4,7,10,13-tetraoxahexadec-15-ynamido)butanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide
[Molecular Formula]

C34H48N4O8S
[MOL File]

2267282-21-1.mol
[Molecular Weight]

672.83
Chemical PropertiesBack Directory
[Boiling point ]

903.991±65.00 °C(Press: 760.00 Torr)(predicted)
[density ]

1.217±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
[storage temp. ]

2-8°C
[form ]

solid
[pka]

14.073±0.40(predicted)
Hazard InformationBack Directory
[Uses]

Protein degrader builiding block (S,R,S)-AHPC-PEG4-Alkyne enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant alkyne for click chemistry with an azide on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant alkyne group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
[reaction suitability]

reaction type: click chemistry
reagent type: ligand-linker conjugate
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