| Identification | Back Directory | [Name]
3-HYDROXY-4,5,6,6A-TETRAHYDRO-3AH-PYRROLO[3,4-D]ISOXAZOLE-4-CARBOXYLIC ACID | [CAS]
227619-64-9 | [Synonyms]
HIP-A
(+/-)-HIP-A
3-HYDROXY-4,5,6,6A-TETRAHYDRO-3AH-PYRROLO[3,4-D]ISOXAZOLE-4-CARBOXYLIC ACID
2H-Pyrrolo[3,4-d]isoxazole-4-carboxylic acid, hexahydro-3-oxo-, (3aR,4S,6aR)-rel- | [Molecular Formula]
C6H8N2O4 | [MDL Number]
MFCD08703102 | [MOL File]
227619-64-9.mol | [Molecular Weight]
172.14 |
| Hazard Information | Back Directory | [Uses]
(+/-)-HIP-A is anew AMPA-kainate receptor agonist. | [Biological Activity]
Potent, non-competitive excitatory amino acid transporter (EAAT) blocker. Preferentially inhibits glutamate-induced [ 3 H]D-aspartate release (IC 50 = 1.6 μ M) rather than [ 3 H]L-glutamate uptake (IC 50 = 18 μ M). Moderately selective; displays no affinity for NMDA and metabotropic glutamate receptors, and low affinity for AMPA and kainate receptors (IC 50 values are 43 and 8 μ M respectively).牋. |
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