| Identification | Back Directory | [Name]
ALE-0540
(ALE0540) | [CAS]
234779-34-1 | [Synonyms]
ALE-0540
ALE-0540
(ALE0540)
1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-[(2-hydroxyethyl)amino]-5-nitro-
2-[(2-hydroxyethyl)amino]-5-nitro-2,3-dihydro-1H-benzo[de]isoquinoline-1,3-dione | [Molecular Formula]
C14H11N3O5 | [MOL File]
234779-34-1.mol | [Molecular Weight]
301.25 |
| Chemical Properties | Back Directory | [Boiling point ]
584.9±60.0 °C(Predicted) | [density ]
1.60±0.1 g/cm3(Predicted) | [form ]
Beige solid. | [pka]
14.49±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
ALE-0540, a nonpeptidic small molecule, is a nerve growth factor receptor antagonist. ALE-0540 inhibits the binding of NGF to tyrosine kinase (Trk) A or both p75 and TrkA with IC50 values of 5.88 μM and 3.72 μM, respectively. ALE-0540 can be used to examine mechanisms leading to the development of agents for the treatment of pain[1]. | [References]
[1] Owolabi JB, et al. Characterization of antiallodynic actions of ALE-0540, a novel nerve growth factor receptor antagonist, in the rat. J Pharmacol Exp Ther. 1999 Jun;289(3):1271-6. PMID:10336516 |
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| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
cjbscvictory
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| Tel: |
13348960310 13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
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