| Identification | Back Directory | [Name]
MEN 11270 | [CAS]
235082-52-7 | [Synonyms]
MEN 11270
L-Arginine, D-arginyl-L-arginyl-L-prolyl-(4R)-4-hydroxy-L-prolylglycyl-3-(2-thienyl)-L-alanyl-(2S)-2,4-diaminobutanoyl-(3R)-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-(2S,3aS,7aS)-octahydro-1H-indole-2-carbonyl-, (10→7)-lactam | [Molecular Formula]
C60H90N20O11S | [MDL Number]
MFCD18252659 | [MOL File]
235082-52-7.mol | [Molecular Weight]
1299.57 |
| Chemical Properties | Back Directory | [density ]
1.60±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble to 1 mg/ml in 30% acetonitrile / water | [form ]
Powder | [pka]
12.72±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
MEN 11270, a cyclic decapeptide, is a B2 kinin receptor antagonist. MEN 11270 bound with high-affinity to the B2 kinin receptor constitutively expressed by WI38 human fibroblasts, inhibiting 3H-bradykinin (BK) with a pKi value of 10.3[1]. | [storage]
Store at -20°C | [References]
[1] Meini S, et, al. MEN 11270, A novel selective constrained peptide antagonist with high affinity at the human B2 kinin receptor. J Pharmacol Exp Ther. 1999 Jun;289(3):1250-6. PMID:10336513 |
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