| Identification | Back Directory | [Name]
ALK/ROS1-IN-1 | [CAS]
2365497-07-8 | [Synonyms]
ALK/ROS1-IN-1
ALK/ROS-1-IN-1,ALK/ROS1 IN 1,ALK/ROS1IN1
3-Piperidinecarboxamide, 1-[2-[[2-methoxy-4-(1-piperazinyl)phenyl]amino]-4-pyridinyl]-N-[[4-(trifluoromethoxy)phenyl]methyl]-, (3S)- | [Molecular Formula]
C30H35F3N6O3 | [MDL Number]
MFCD34469937 | [MOL File]
2365497-07-8.mol | [Molecular Weight]
584.63 |
| Hazard Information | Back Directory | [Uses]
ALK/ROS1-IN-1 (compound 2e) is a potent and selective anti crizotinib-resistant ALK/ROS1 dual inhibitor, with IC50s of 0.174 μM and 0.530 μM for ALK and ROS1 enzyme, respectively. | [References]
[1] Liu S, et al. Design, synthesis and biological evaluations of 2-amino-4-(1-piperidine) pyridine derivatives as novel anti crizotinib-resistant ALK/ROS1 dual inhibitors. Eur J Med Chem. 2019 Oct 1;179:358-375. DOI:10.1016/j.ejmech.2019.06.043 |
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| Company Name: |
BOC Sciences
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1-631-485-4226; 16314854226 |
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https://www.bocsci.com |
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