| Identification | Back Directory | [Name]
tert-butyl 2-(4-isopropoxybenzamido)-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate | [CAS]
2375541-45-8 | [Synonyms]
187407
Autogramin-2
tert-butyl 2-(4-isopropoxybenzamido)-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate
Thiazolo[5,4-c]pyridine-5(4H)-carboxylic acid, 6,7-dihydro-2-[[4-(1-methylethoxy)benzoyl]amino]-, 1,1-dimethylethyl ester | [Molecular Formula]
C21H27N3O4S | [MDL Number]
MFCD32174286 | [MOL File]
2375541-45-8.mol | [Molecular Weight]
417.52 |
| Chemical Properties | Back Directory | [density ]
1.252±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO (up t0 25 mg/ml) or in Ethanol (up to 25 mg/ml) | [form ]
solid | [pka]
7.59±0.20(Predicted) | [color ]
Off-white | [Stability:]
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
| Hazard Information | Back Directory | [Description]
Autogramin-2 (2375541-45-8) is an inhibitor of autophagy (autophagy induced by amino acid starvation IC50 = 270 nM; Rapamycin IC50 = 140 nM) acting via selective targeting of the cholesterol transfer protein GRAM domain-containing protein 1A (GRAMD1A).? Autogramin-2 inhibition of GRAMD1A inhibits biogenesis of the autophagosome. | [Uses]
Autogramin-2 potently inhibits autophagy induced by either starvation (IC50=0.27 μM) or mTORC1 inhibition (Rapamycin; IC50=0.14 μM)[1]. | [References]
1.Laraia et al. (2019), The cholesterol transfer protein GRAMD1A regulates autophagosome biogenesis; Chem. Biol., 15 710 |
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