| Identification | Back Directory | [Name]
LDC7559 | [CAS]
2407782-01-6 | [Synonyms]
LDC7559
Acetamide, N-[2-(2-methoxyphenyl)-4H,10H-pyrazolo[5,1-c][1,4]benzoxazepin-7-yl]- | [Molecular Formula]
C20H19N3O3 | [MOL File]
2407782-01-6.mol | [Molecular Weight]
349.38 |
| Chemical Properties | Back Directory | [Boiling point ]
596.3±50.0 °C(Predicted) | [density ]
1.29±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 125 mg/mL (357.78 mM) | [form ]
Solid | [pka]
14.44±0.20(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Description]
LDC7559 is a gasdermin D (GSDMD) inhibitor via blocking neutrophil extracellular trap (NET) in the late stages. | [Uses]
LDC7559 is a gasdermin D (GSDMD) inhibitor via blocking neutrophil extracellular trap (NET) in the late stages [1]. | [in vitro]
LDC7559 (1 and 5 μM) inhibits IL-1β release upon inflammasome activation, and significantly blocks the lethal effect of both human and murine GSDMD NT domains transfected into HEK293T cells.
LDC7559 functions directly through blocking the activity of the GSDMD NT domain, rather than interfering with the activation and cleavage process. | [References]
[1] Spel L, et al. Gasdermin D opens the way for NETs. Nat Rev Rheumatol. 2018 Dec;14(12):690-692. DOI:10.1038/s41584-018-0124-3
[2] Sollberger G, et al. Gasdermin D plays a vital role in the generation of neutrophil extracellular traps. Sci Immunol. 2018 Aug 24;3(26). pii: eaar6689. DOI:10.1126/sciimmunol.aar6689
[3] Ankit Pandeya, et al. Gasdermin D (GSDMD) as a New Target for the Treatment of Infection. Medchemcomm. 2019 Apr 4;10(5):660-667. DOI:10.1039/c9md00059c |
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