| Identification | Back Directory | [Name]
Bempedoic Acid-d4 | [CAS]
2408131-70-2 | [Synonyms]
Bempedoic Acid-d4
8-Hydroxy-2,2,14,14-tetramethylpentadecanedioic-7,7,9,9-d4 acid
Bempedoic acid-D4Q: What is
Bempedoic acid-D4 Q: What is the CAS Number of
Bempedoic acid-D4 | [Molecular Formula]
C19H36O5 | [MOL File]
2408131-70-2.mol | [Molecular Weight]
344.49 |
| Hazard Information | Back Directory | [Uses]
Bempedoic acid-d4 is the deuterium labeled Bempedoic acid. Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor. Bempedoic acid (ETC-1002) activates AMPK[1][2]. | [References]
[1] Pinkosky SL, et al. AMP-activated protein kinase and ATP-citrate lyase are two distinct molecular targets for ETC-1002, a novel small molecule regulator of lipid and carbohydrate metabolism. J Lipid Res. 2013 Jan;54(1):134-51. DOI:10.1194/jlr.M030528
[2] Filippov S, et al. ETC-1002 regulates immune response, leukocyte homing, and adipose tissue inflammation via LKB1-dependent activation of macrophage AMPK. J Lipid Res. 2013 Aug;54(8):2095-108. DOI:10.1194/jlr.M035212
[3] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110 |
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