| Identification | Back Directory | [Name]
Acetamide, 2-[[3-[4-(aminosulfonyl)phenyl]-3,4-dihydro-4-oxo-2-quinazolinyl]thio]-N-2-pyrazinyl- | [CAS]
2419107-97-2 | [Synonyms]
NF-κB/PON1-IN-1
Acetamide, 2-[[3-[4-(aminosulfonyl)phenyl]-3,4-dihydro-4-oxo-2-quinazolinyl]thio]-N-2-pyrazinyl- | [Molecular Formula]
C20H16N6O4S2 | [MOL File]
2419107-97-2.mol | [Molecular Weight]
468.51 |
| Hazard Information | Back Directory | [Uses]
NF-κB/PON1-IN-1 (Compound 16) is a NF-κB/PON1 pathway inhibitor. NF-κB/PON1-IN-1 has antioxidant (IC50 = 45.76 μM) and hepatoprotective activities[1]. | [References]
[1] Soliman AM, et al. Antioxidant activity of novel quinazolinones bearing sulfonamide: Potential radiomodulatory effects on liver tissues via NF-κB/ PON1 pathway. Eur J Med Chem. 2020 Jul 1;197:112333. DOI:10.1016/j.ejmech.2020.112333 |
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