| Identification | Back Directory | [Name]
Benzonitrile, 2-[[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]methyl]-4-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)- | [CAS]
2425805-22-5 | [Synonyms]
HCV-IN-34
Benzonitrile, 2-[[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]methyl]-4-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)- | [Molecular Formula]
C31H36ClN5 | [MOL File]
2425805-22-5.mol | [Molecular Weight]
514.11 |
| Hazard Information | Back Directory | [Uses]
HCV-IN-34 (compound 3i) is an orally active and potent HCV entry inhibitor. HCV-IN-35 shows excellent antiviral activity, with an EC50 of 0.010 μM and a CC50 (half-maximal cytotoxic concentration) of 8.23 μM[1]. | [References]
[1] Wang Y, Li J, Tan J, Yang B, Quan Y, Peng Z, Li Y, Li Z. Design, Synthesis, and Biological Evaluation of 2-((4-Bisarylmethyl-piperazin-1-yl)methyl)benzonitrile Derivatives as HCV Entry Inhibitors. J Med Chem. 2022 Feb 10;65(3):2107-2121. DOI:10.1021/acs.jmedchem.1c01637 |
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