| Identification | Back Directory | [Name]
carboquone | [CAS]
24279-91-2 | [Synonyms]
Esquinon
arbamate
DK340000
Esquinone
NSC 134679
carboquone
Carbazilquinone
Carbazylquinone
carboquone USP/EP/BP
SHHKQEUPHAENFK-UHFFFAOYSA-N
p-Benzoquinone, 2,5-bis(1-aziridinyl)-3-(2-hydroxy-1-methoxyethyl)-6-methyl-, carbamate (ester) (8CI)
2-[2-[(Aminocarbonyl)oxy]-1-methoxyethyl]-3,6-bis(1-aziridinyl)-5-methyl-2,5-cyclohexadiene-1,4-dione
2,5-Cyclohexadiene-1,4-dione, 2-[2-[(aminocarbonyl)oxy]-1-methoxyethyl]-3,6-bis(1-aziridinyl)-5-methyl- | [Molecular Formula]
C15H19N3O5 | [MOL File]
24279-91-2.mol | [Molecular Weight]
321.33 |
| Chemical Properties | Back Directory | [Melting point ]
202° (dec) | [Boiling point ]
460.09°C (rough estimate) | [density ]
1.1990 (rough estimate) | [refractive index ]
1.5600 (estimate) | [pka]
13.14±0.50(Predicted) | [color ]
Red to reddish-brown crystals |
| Hazard Information | Back Directory | [Originator]
Esquinon,Sankyo,Japan,1974 | [Definition]
ChEBI: Carboquone is an organic molecular entity. | [Manufacturing Process]
In 10 ml of ethanol was dissolved with heating 200 mg of 2-methyl-5-(1-
methoxy-2-carbamoyloxyethyl)-1,4-benzoquinone and the resulting solution
was cooled. To the cooled solution was added 0.5 ml of aziridine and then the
resulting mixture was allowed to stand in a refrigerator at 5°C to 8°C for 4
days. Thereafter, the crystalline substance which precipitated in situ was
recovered by filtration and washed with ethanol to give 50 mg of the desired
product as red crystals melting at 200°C (with decomposition). | [Therapeutic Function]
Antineoplastic | [Safety Profile]
A poison via ingestion,intraperitoneal, subcutaneous, and intravenous routes.Mutation data reported. When heated to decomposition itemits toxic NOx. |
| Safety Data | Back Directory | [Toxicity]
LD50 in male mice, male rats (mg/kg): 6.09, 3.88 i.v.; 3.84, 3.16 i.p.; 30.8, 28.0 orally (Masuda, Suzuki) |
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