| Identification | Back Directory | [Name]
1-Piperazinepropanamide, 4-[4-(1-methylethyl)benzoyl]-N-(1,2,3,4-tetrahydro-1,3-dimethyl-2,4-dioxo-5-pyrimidinyl)-N-[[3-(trifluoromethyl)phenyl]methyl]- | [CAS]
2439177-97-4 | [Synonyms]
ALDH1A1-IN-3
1-Piperazinepropanamide, 4-[4-(1-methylethyl)benzoyl]-N-(1,2,3,4-tetrahydro-1,3-dimethyl-2,4-dioxo-5-pyrimidinyl)-N-[[3-(trifluoromethyl)phenyl]methyl]- | [Molecular Formula]
C31H36F3N5O4 | [MOL File]
2439177-97-4.mol | [Molecular Weight]
599.64 |
| Hazard Information | Back Directory | [Uses]
ALDH1A1-IN-3 (compound 57) is an excellent and selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitor with an IC50 value of 0.379 μM. ALDH1A1-IN-3 can effectively improve glucose consumption in HepG2 cells. ALDH1A1-IN-3 can be used for researching glucose metabolism improvement[1]. | [References]
[1] Ma Z, et al. Design, synthesis of 1,3-dimethylpyrimidine-2,4-diones as potent and selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with glucose consumption improving activity. Bioorg Chem. 2020 Aug;101:103971. DOI:10.1016/j.bioorg.2020.103971 |
|
|