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ChemicalBook--->CAS DataBase List--->2449086-91-1

2449086-91-1

2449086-91-1 Structure

2449086-91-1 Structure
IdentificationBack Directory
[Name]

Ormutivimab
[CAS]

2449086-91-1
[Synonyms]

Ormutivimab
Research Grade Ormutivimab (DVV03905)
Hazard InformationBack Directory
[Uses]

Ormutivimab (rhRIG) is a recombinant human monoclonal antibody, targeting rabies virus. Ormutivimab neutralizes a variety of rabies virus strains. Ormutivimab exhibits potent potency against rabies post-exposure prophylaxis (PEP) model[1][2].
[in vivo]

Ormutivimab (20 IU/kg; i.m.; single dose) protects beagles from a lethal challenge of street RABV BD06[1].
Ormutivimab (20 IU/kg, 100 IU/kg; i.m.; single dose) protects challenged Kunming mice against various rabies virus[1].

Animal Model:Balb/c mice challenge model with rabies virus[1]
Dosage:20 IU/kg, 100 IU/kg
Administration:Intramuscular injection; single dose after 4 hr after infection
Result:Protected mice from rabies CVS-24 and GZ-1 isolates at a comparable rate (90%) to that of HRIG, human antirabies immune globulin.
[References]

[1] Zhai LL, et al. Efficacy of ormutivimab, a novel recombinant human anti-rabies monoclonal antibody, in post-exposure prophylaxis animal models. Travel Med Infect Dis. 2022 Mar-Apr;46:102267. DOI:10.1016/j.tmaid.2022.102267
[2] Zhang J, et al. Population Pharmacodynamic Analyses of Human Anti-Rabies Virus Monoclonal Antibody (Ormutivimab) in Healthy Adult Subjects. Vaccines (Basel). 2022 Jul 29;10(8):1218. DOI:10.3390/vaccines10081218
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