| Identification | Back Directory | [Name]
1H-Pyridazino[4,5-e][1,3,4]thiadiazin-5(6H)-one, 3-[[(2,4-dichlorophenyl)methyl]thio]-1,6-dimethyl- | [CAS]
245728-44-3 | [Synonyms]
BTB09089
GPR65 agonist (BTB09089)
1H-Pyridazino[4,5-e][1,3,4]thiadiazin-5(6H)-one, 3-[[(2,4-dichlorophenyl)methyl]thio]-1,6-dimethyl- | [Molecular Formula]
C14H12Cl2N4OS2 | [MOL File]
245728-44-3.mol | [Molecular Weight]
387.31 |
| Chemical Properties | Back Directory | [Boiling point ]
500.6±60.0 °C(Predicted) | [density ]
1.57±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
-0.51±0.40(Predicted) | [color ]
Yellow to orange |
| Hazard Information | Back Directory | [Uses]
BTB09089 is a T cell death-associated gene 8 (TDAG8/GPR65) specific agonist. BTB09089 increases TDAG8 expression and regulates the cytokine production of T cells and macrophages[1]. | [in vivo]
BTB09089 (5-20 μM, 8 μL; i.c.v.; 6 hours prior to MCAO) reduces cerebral ischaemia-reperfusion injury in rats[2]. | Animal Model: | Adult male SD rats (270-280 g), middle cerebral artery occlusion (MCAO) model[2] | | Dosage: | 5, 10 and 20 μM, 8 μL | | Administration: | Intracerebroventricular injection, six hours prior to MCAO | | Result: | Up-regulated TDAG8 and Bcl-2 expression and down-regulated cleaved caspase-3 expression, while the infarction volume was reduced, and neurological deficits were ameliorated 24 and 72 h after MCAO. |
| [References]
[1] Onozawa Y, et al. Activation of T cell death-associated gene 8 regulates the cytokine production of T cells and macrophages in vitro. Eur J Pharmacol. 2012 May 15;683(1-3):325-31. DOI:10.1016/j.ejphar.2012.03.007
[2] Ma XD, et al. TDAG8 activation attenuates cerebral ischaemia-reperfusion injury via Akt signalling in rats. Exp Neurol. 2017 Jul;293:115-123. DOI:10.1016/j.expneurol.2017.03.023 |
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