| Identification | Back Directory | [Name]
2-Propenoic acid, 3-[(2R,3R)-2,3-dihydro-2-(4-hydroxyphenyl)-3-methyl-5-benzofuranyl]-, (2E)-rel- | [CAS]
2477608-96-9 | [Synonyms]
Antileishmanial agent-8
2-Propenoic acid, 3-[(2R,3R)-2,3-dihydro-2-(4-hydroxyphenyl)-3-methyl-5-benzofuranyl]-, (2E)-rel- | [Molecular Formula]
C18H16O4 | [MOL File]
2477608-96-9.mol | [Molecular Weight]
296.32 |
| Hazard Information | Back Directory | [Uses]
Antileishmanial agent-8 (compound 18) has potent and selective activity against Leishmania donovani (L. donovani) with an IC50 value of 5.64 μM. Antileishmanial agent-8 has relatively low cytotoxicity in L-6 cells (IC50=73.9 μM)[1]. | [References]
[1] Bernal FA, et al. (±)-trans-2-phenyl-2,3-dihydrobenzofurans as leishmanicidal agents: Synthesis, in?vitro evaluation and SAR analysis.?Eur J Med Chem. 2020;205:112493. DOI:10.1016/j.ejmech.2020.112493 |
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