Identification | Back Directory | [Name]
Benzonitrile, 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-6,7-dimethoxy-2-quinazolinyl]amino]- | [CAS]
2554620-04-9 | [Synonyms]
HIV-1 inhibitor-21 Benzonitrile, 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-6,7-dimethoxy-2-quinazolinyl]amino]- | [Molecular Formula]
C28H24N6O2 | [MOL File]
2554620-04-9.mol | [Molecular Weight]
476.53 |
Hazard Information | Back Directory | [Uses]
HIV-1 inhibitor-21 (compound 9b) is a potent HIV-1 non-nucleoside reverse transcriptase (RT) inhibitor, with an IC50 value of 0.55 μM for HIV-1 RT. HIV-1 inhibitor-21 has antiretroviral activity against HIV-1 WT and K103N strains with EC50s of 12.7 nM and 10.4 nM, and has relatively low cytotoxicity (MT-4?cells CC50?=10.2?μM)[1]. | [IC 50]
HIV-1 (WT): 12.7 nM (EC50); HIV-1 (K103N): 10.4 nM (EC50) | [References]
[1] Han S, et al. Fragment hopping-based discovery of novel sulfinylacetamide-diarylpyrimidines (DAPYs) as HIV-1 nonnucleoside reverse transcriptase inhibitors. Eur J Med Chem. 2020;185:111874. DOI:10.1016/j.ejmech.2019.111874 |
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