| Identification | Back Directory | [Name]
4-PYRROLIDIN-1-YLANILINE | [CAS]
2632-65-7 | [Synonyms]
AKOS B021942
AKOS BB-8560
TIMTEC-BB SBB009578
ART-CHEM-BB B021942
4-pyrrolidinoaniline
4-PYRROLIDIN-1-YLANILINE
4-(1-PYRROLIDINYL)ANILINE
1-(4-Aminophenyl)pyrrolidine
4-(1-pyrrolidinyl)phenylamine
4-PYRROLIDIN-1-YL-PHENYLAMINE
BenzenaMine,4-(1-pyrrolidinyl)- | [Molecular Formula]
C10H14N2 | [MDL Number]
MFCD00156245 | [MOL File]
2632-65-7.mol | [Molecular Weight]
162.23 |
| Chemical Properties | Back Directory | [Melting point ]
51 °C | [Boiling point ]
180-185 °C(Press: 16 Torr) | [density ]
1.109±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [pka]
7.20±0.40(Predicted) | [Appearance]
Brown to black Solid |
| Hazard Information | Back Directory | [Synthesis]
GENERAL PROCEDURE: The general method for the synthesis of 4-(pyrrolidin-1-yl)aniline from 1-(4-nitrophenyl)pyrrolidine is as follows: 1-(substituted)4-nitrophenyl derivatives IVa, b, e, f (0.01 mol) were dissolved in NH4OH (20 mL, 30%) and an aqueous solution of sodium conidiosulfite (7 g, 0.04 mol) was quickly added (30 mL). The reaction mixture was refluxed for 15 min. After completion of the reaction, the mixture was cooled and the crude product was obtained by filtration. The crude product was washed and crystallized from dichloromethane to give the target compounds Va, b, e, f. Among them, 4-(pyrrolidin-1-yl)aniline Vb was obtained in 80% yield as a yellow oily substance (in agreement with the literature report) [66]. | [References]
[1] Bulletin of the Korean Chemical Society, 2015, vol. 36, # 7, p. 1863 - 1873
[2] Bioorganic Chemistry, 2014, vol. 57, p. 65 - 82
[3] Advanced Synthesis and Catalysis, 2018, vol. 360, # 11, p. 2131 - 2137
[4] Patent: US2005/49286, 2005, A1
[5] Justus Liebigs Annalen der Chemie, 1955, vol. 596, p. 1,151 |
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