| Identification | Back Directory | [Name]
Benzo[b]thiophen-4-amine, 7-(3,4-dichlorophenyl)-4,5,6,7-tetrahydro-N-[2-(tetrahydro-2H-pyran-4-yl)ethyl]-, hydrochloride (1:1) | [CAS]
2640054-39-1 | [Synonyms]
Antifungal agent 22
Benzo[b]thiophen-4-amine, 7-(3,4-dichlorophenyl)-4,5,6,7-tetrahydro-N-[2-(tetrahydro-2H-pyran-4-yl)ethyl]-, hydrochloride (1:1) | [Molecular Formula]
C21H26Cl3NOS | [MOL File]
2640054-39-1.mol | [Molecular Weight]
446.86 |
| Hazard Information | Back Directory | [Uses]
Antifungal agent 22 (compound D16) is a potential and orally active antifungal agent for CM (cryptococcal meningitis), with an IC50 of 0.5 μg/mL. Antifungal agent 22 can penetrate the blood-brain barrier and kill the C. neoformans H99 cells by destroying the integrity of fungal cell membranes. Antifungal agent 22 shows selective anti-Cryptococcus activity with good metabolic stability and low cytotoxicity[1]. | [in vivo]
Antifungal agent 22 (D16) (15 mg/kg, Intragastrically, daily for 5 days) shows potent anti-Cryptococcal efficacy[1]. | Animal Model: | ICR female mice (18-22 g, 4-6 weeks, tail vein injected with C. neoformans H99 cells)[1] | | Dosage: | 15 mg/kg | | Administration: | Intragastrically, daily for 5 days | | Result: | Showed potent anti-Cryptococcal efficacy, significantly reduced the number of C. neoformans H99 cells in the brain after 5 days, prolong the median survival time (14 days) of the infected mice at a dose of 15 mg/kg. |
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