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ChemicalBook--->CAS DataBase List--->2642137-96-8

2642137-96-8

2642137-96-8 Structure

2642137-96-8 Structure
IdentificationBack Directory
[Name]

Benzonitrile, 5-(2,3-dihydro-3-oxo-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-2-(1-methylethoxy)-
[CAS]

2642137-96-8
[Synonyms]

Xanthine oxidase-IN-4
Benzonitrile, 5-(2,3-dihydro-3-oxo-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-2-(1-methylethoxy)-
[Molecular Formula]

C15H13N5O2
[MOL File]

2642137-96-8.mol
[Molecular Weight]

295.3
Chemical PropertiesBack Directory
[Boiling point ]

404.2±45.0 °C(Predicted)
[density ]

1.40±0.1 g/cm3(Predicted)
[pka]

5.93±0.20(Predicted)
Hazard InformationBack Directory
[Uses]

Xanthine oxidase-IN-4 (compound 19a) is an orally active and potent xanthine oxidase (XO) inhibitor, with an IC50 of 0.039 μM. Xanthine oxidase-IN-4 exhibits hypouricemic potency in potassium oxonate induced hyperuricemia rats. Xanthine oxidase-IN-4 can be used for hyperuricemia and gout research[1].
[in vivo]

Xanthine oxidase-IN-4 (compound 19a) (SD rats, 10 mg/kg, Intragastrically, once) significantly reduces the serum concentration of uric acid[1].

Animal Model:Sprague-Dawley rats (Six weeks, male, 180-200g, six groups)[1]
Dosage:10 mg/kg
Administration:Intragastrically, once
Result:Significantly reduced the serum concentration of uric acid, with AUC (uric acid, 1-5 h) of 44.3%.
[References]

[1] Zhao J, et al. Intramolecular hydrogen bond interruption and scaffold hopping of TMC-5 led to 2-(4-alkoxy-3-cyanophenyl)pyrimidine-4/5-carboxylic acids and 6-(4-alkoxy-3-cyanophenyl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-ones as potent pyrimidine-based xanthine oxidase inhibitors. Eur J Med Chem. 2022;229:114086. DOI:10.1016/j.ejmech.2021.114086
2642137-96-8 suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +8613564774135 , +8613564774135
Website:
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
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