| Identification | Back Directory | [Name]
2-Piperazineacetonitrile, 4-[(7R)-7-(3,4-dihydro-1(2H)-quinolinyl)-5,6,7,8-tetrahydro-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]-4-quinazolinyl]-1-(1-oxo-2-propen-1-yl)-, (2S)- | [CAS]
2734060-73-0 | [Synonyms]
KRAS G12C inhibitor 25
2-Piperazineacetonitrile, 4-[(7R)-7-(3,4-dihydro-1(2H)-quinolinyl)-5,6,7,8-tetrahydro-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]-4-quinazolinyl]-1-(1-oxo-2-propen-1-yl)-, (2S)- | [Molecular Formula]
C32H41N7O2 | [MOL File]
2734060-73-0.mol | [Molecular Weight]
555.71 |
| Hazard Information | Back Directory | [Uses]
KRAS G12C inhibitor 25 is a KRAS G12C inhibitor. KRAS G12C inhibitor 25 inhibits SOSl-assisted GDP/GTP exchanging activity of KRAS-G12C mutant (IC50=0.48 nM). From WO2021216770A1 compound 3[1]. | [IC 50]
KRas G12C | [References]
[1] Yimin Qian, et al. Substituted tetrahydroquinazoline compounds as kras inhibitors. WO2021216770A1. |
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