| Identification | Back Directory | [Name]
PYRAZOLO[1,5-A]PYRIMIDINE | [CAS]
274-71-5 | [Synonyms]
PYRAZOLO[1,5-A]PYRIMIDINE
pyrazolo[2,3-a]pyrimidine | [Molecular Formula]
C6H5N3 | [MDL Number]
MFCD10699580 | [MOL File]
274-71-5.mol | [Molecular Weight]
119.13 |
| Chemical Properties | Back Directory | [Melting point ]
105 °C | [density ]
1.29±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [pka]
0.33±0.30(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Chemical Properties]
Light yellow solid | [Uses]
Pyrazolo[1,5-a]pyrimidine is being researched as a protein kinase CK2 inhibitors. | [Synthesis]
Preparation of compound 23a: 1H-pyrazol-3-ylamine (32 g, 0.386 mol) and (E)-3-dimethylaminoacrylaldehyde (38.2 g, 0.386 mol) were dissolved in ethanol (500 mL), and the reaction was carried out at reflux for 6 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure and the resulting residue was purified by column chromatography (eluent: petroleum ether/ethyl acetate = 10:1 to 2:1) to afford the target product, pyrazolo[1,5-a]pyrimidine 23a, as a white solid (30 g, 65% yield). | [References]
[1] Synthesis, 2006, # 1, p. 59 - 62
[2] Patent: WO2010/16005, 2010, A1. Location in patent: Page/Page column 116 |
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