| Identification | Back Directory | [Name]
IMIDAZO[1,2-A]PYRAZINE | [CAS]
274-79-3 | [Synonyms]
Zinc02569196
1,3a,6-Triazaindene
1,7-Diazaindolizine
IMIDAZO[1,2-A]PYRAZINE
HIMIDAZO(1,2-A)PYRAZINE
IMIDAZO[1,2-A]PYRAZINE ISO 9001：2015 REACH | [Molecular Formula]
C6H5N3 | [MDL Number]
MFCD06245371 | [MOL File]
274-79-3.mol | [Molecular Weight]
119.12 |
| Chemical Properties | Back Directory | [Melting point ]
90-94 °C | [density ]
1.29 | [storage temp. ]
Sealed in dry,Room Temperature | [form ]
solid | [pka]
4.30±0.30(Predicted) | [color ]
dark brown | [InChI]
InChI=1S/C6H5N3/c1-3-9-4-2-8-6(9)5-7-1/h1-5H | [InChIKey]
MBVAHHOKMIRXLP-UHFFFAOYSA-N | [SMILES]
C12=NC=CN1C=CN=C2 |
| Hazard Information | Back Directory | [Uses]
Imidazo[1,2-a]pyrazine is a biochemical reagent that can be used as a biological material or organic compound for life science related research[1]. | [Definition]
ChEBI: Imidazo[1,2-a]pyrazine is an imidazopyrazine, a polycyclic heteroarene and an azaarene. | [Synthesis]
Pyrazin-2-amine (5 g, 52 mmol) and 40% 2-chloroacetaldehyde solution (15 mL, 78 mmol) were used as raw materials and sodium bicarbonate (6.60 g, 78 mmol) was added as base. The reaction mixture was stirred at 100 °C for 48 hours. After completion of the reaction, it was cooled to room temperature and neutralized by adding 100 mL of saturated potassium carbonate solution, followed by extraction with dichloromethane (100 mL x 3). The organic phases were combined, dried with anhydrous sodium sulfate and filtered to remove the desiccant. The filtrate was concentrated under reduced pressure to afford the target product imidazo[1,2-a]pyrazine (3 g, 50.0% yield) as a brown solid. Mass spectrometry analysis (ESI) showed m/z: 120.1 [M + 1]. | [References]
[1] Bergmeyer H U, et al. Biochemical reagents[M]//Methods of Enzymatic Analysis. Academic Press, 1965: 967-1037. |
|
|