| Identification | Back Directory | [Name]
3-Chloro-4-[4-[4-fluoro-2-(trifluoromethyl)phenoxy]-5,8-dihydropyrido[3,4-d]pyrimidin-7(6H)-yl]-1H-pyrrole-2,5-dione | [CAS]
2762315-39-7 | [Synonyms]
3-Chloro-4-[4-[4-fluoro-2-(trifluoromethyl)phenoxy]-5,8-dihydropyrido[3,4-d]pyrimidin-7(6H)-yl]-1H-pyrrole-2,5-dione | [Molecular Formula]
C18H11ClF4N4O3 | [MOL File]
2762315-39-7.mol | [Molecular Weight]
442.75 |
| Hazard Information | Back Directory | [Uses]
TRPC5-IN-4 is potent and safe TRPC inhibitor with IC50 value of 14.07 nM and 65 nM for TRPC5 and TRPC4, respectively. TRPC5-IN-4 shows no damage on the cellular component of liver and kidney. TRPC5-IN-4 can be used for the research of chronic kidney disease (CKD)[1]. | [IC 50]
TRPC5: 14.07 nM (IC50); TRPC4: 65 nM (IC50) | [References]
[1] Zhang Z, Chen L, Tian H, et al. Discovery of pyrroledione analogs as potent transient receptor potential canonical channel 5 inhibitors. Bioorg Med Chem Lett. 2022;61:128612. DOI:10.1016/j.bmcl.2022.128612 |
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