104-88-1

276866-90-1

The general procedure for the synthesis of 3-iodo-4-chlorobenzaldehyde from 4-chlorobenzaldehyde was as follows: iodine (1.12 g, 4.4 mmol) and sodium iodate (400 mg, 2.2 mmol) were added to a reaction vessel containing sulphuric acid (30 ml), and stirred at room temperature for 30 minutes. Subsequently, 4-chlorobenzaldehyde (1.40 g, 10.0 mmol) was added to the reaction mixture and stirring was continued for 1 hour at room temperature. After completion of the reaction, the reaction mixture was poured into ice water and the resulting solid was separated by filtration. After washing the solid with water to neutral, the solid was dissolved in ethanol and recrystallized to give 1.06 g (4.00 mmol, 40% yield) of 3-iodo-4-chlorobenzaldehyde.