| Identification | Back Directory | [Name]
2,4-Pyrimidinediamine, N4-(8-methyl-4-cinnolinyl)-N2-[4-(4-piperidinylmethyl)phenyl]- | [CAS]
2785430-84-2 | [Synonyms]
ALK5-IN-28
2,4-Pyrimidinediamine, N4-(8-methyl-4-cinnolinyl)-N2-[4-(4-piperidinylmethyl)phenyl]- | [Molecular Formula]
C25H27N7 | [MOL File]
2785430-84-2.mol | [Molecular Weight]
425.53 |
| Hazard Information | Back Directory | [Uses]
ALK5-IN-28 (compound Ex-05) is a selective ALK-5 inhibitor (IC50≤10 nM), inhibits TGF-β-induced SMAD signaling. ALK5-IN-28 has the potential to inhibit growth of tumour in vivo. ALK5-IN-28 can be used in study of proliferative diseases such as cancer, fibrotic diseases, and systemic sclerosis[1]. | [IC 50]
ALK5: ≤10 nM (IC50) | [References]
[1] Bettina FRANZ, et al. Alk-5 inhibitors and uses thereof. Patent WO2022126133A1. |
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