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ChemicalBook--->CAS DataBase List--->2867519-91-1

2867519-91-1

2867519-91-1 Structure

2867519-91-1 Structure
IdentificationBack Directory
[Name]

TMX-4153
[CAS]

2867519-91-1
[Synonyms]

TMX-4153
[Molecular Formula]

C59H67ClN10O6S
[MOL File]

2867519-91-1.mol
[Molecular Weight]

1079.75
Chemical PropertiesBack Directory
[density ]

1.369±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
[form ]

Solid
[pka]

13.973±0.40(predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

TMX-4153 is a bivalent degrader. TMX-4153 rapidly and selectively degrades endogenous PIP4K2C by recruiting the von Hippel-Lindau (VHL) E3 ligase complex, with a KD value of 42 nM. TMX-4153 can be used to synthesize PROTAC[1].
[References]

[1] Teng M, et al. Targeting the Dark Lipid Kinase PIP4K2C with a Potent and Selective Binder and Degrader. Angew Chem Int Ed Engl. 2023 Apr 24;62(18):e202302364. DOI:10.1002/anie.202302364
2867519-91-1 suppliers list
Company Name: Dezhou LonWel Pharmaceutical Technology Co., Ltd.  
Tel: 13761310616
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Company Name: Shanghai Tachizaki Biomedical Research Center  
Tel: 18014399201
Website: http://www.chemlab-tachizaki.com/
Company Name: Henan Inokai New Materials Co., Ltd  
Tel: 13253687330
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