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ChemicalBook--->CAS DataBase List--->2873383-67-4

2873383-67-4

2873383-67-4 Structure

2873383-67-4 Structure
IdentificationBack Directory
[Name]

Methanone, [4-(2-furanyl)-1-(2-pyrimidinyl)-1H-pyrrol-3-yl](3,4,5-trimethoxyphenyl)-
[CAS]

2873383-67-4
[Synonyms]

Tubulin inhibitor 30
Methanone, [4-(2-furanyl)-1-(2-pyrimidinyl)-1H-pyrrol-3-yl](3,4,5-trimethoxyphenyl)-
[Molecular Formula]

C22H19N3O5
[MOL File]

2873383-67-4.mol
[Molecular Weight]

405.4
Chemical PropertiesBack Directory
[Boiling point ]

669.3±65.0 °C(Predicted)
[density ]

1.29±0.1 g/cm3(Predicted)
[form ]

Solid
[pka]

-2.46±0.33(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

Tubulin inhibitor 30 (Compound 15) is a tubulin assembly inhibitor with an IC50 of 0.52 μM. Tubulin inhibitor 30 can induce ferroptosis[1].
[in vivo]

Tubulin inhibitor 30 (Compound 15) (25mg/kg; i.p.; every 2 days) inhibits the in vivo tumorigenicity of the human GBM cell line U-87 MG and the human OC cell line SKOV-3, and causes oxidative stress injury and Fe2+ accumulation in mice[1].

Animal Model:BALB/Cnu/nu mice, U-87 MG or SKOV-3 model[1]
Dosage:25 mg/kg
Administration:Intraperitoneal injection, every 2 days
Result:Inhibited tumorigenicity and tumor volume. Caused oxidative stress injury and Fe2+ accumulation.
[References]

[1] Puxeddu M, et al. Induction of Ferroptosis in Glioblastoma and Ovarian Cancers by a New Pyrrole Tubulin Assembly Inhibitor. J Med Chem. 2022 Nov 17. DOI:10.1021/acs.jmedchem.2c01457
2873383-67-4 suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354 , +17819995354
Website:
Company Name: Shanghai Chaolan Chemical Technology Center  
Tel: 021-QQ:65489617 15618227136
Website: www.atkchemical.com/
Company Name: Nantong Hanfang Biotechnology Co. , Ltd.  
Tel: hanfangpharma@126.com; 18616537568
Website: https://hanfangpharma@126.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
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