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Carbonic anhydrase inhibitor 12 is a potent CA II inhibitor, also has inhibitory activity in CA I (Kis of 1.72 and 271 nM in CA II and CA I, respectively). Carbonic anhydrase inhibitor 12 has potent anticancer activity against different cancer cell lines[1]. | [IC 50]
CA Ⅱ | [References]
[1] Abdel-Mohsen HT, et al. Application of the dual-tail approach for the design and synthesis of novel Thiopyrimidine-Benzenesulfonamide hybrids as selective carbonic anhydrase inhibitors.?Eur J Med Chem. 2022;228:114004. DOI:10.1016/j.ejmech.2021.114004 |
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