| Identification | Back Directory | [Name]
benzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-[[3-[[(2S)-4-methyl-2-[[(2S)-4-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]pentanoyl]amino]-2-oxopropyl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate | [CAS]
313664-40-3 | [Synonyms]
(Z-LL)2 Ketone >=98% (HPLC)
1,3-Bis-(Z-Leu-Leu)-diaminoacetone
1,3-Bis-(Z-Leu-Leu)-diaminoacetone Z-Leu-Leu-NH-CH2-CO-CH2-NH-Leu-Leu-Z
L-Leucinamide, 2,2'-(2-oxo-1,3-propanediyl)bis[N-[(phenylmethoxy)carbonyl]-L-leucyl-
benzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-[[3-[[(2S)-4-methyl-2-[[(2S)-4-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]pentanoyl]amino]-2-oxopropyl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate | [Molecular Formula]
C43H64N6O9 | [MDL Number]
MFCD04974180 | [MOL File]
313664-40-3.mol | [Molecular Weight]
809 |
| Chemical Properties | Back Directory | [Boiling point ]
1022.8±65.0 °C(Predicted) | [density ]
1.139±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [form ]
powder | [pka]
10.83±0.46(Predicted) | [color ]
white to light yellow |
| Hazard Information | Back Directory | [Uses]
(Z-LL)2 Ketone is a putative inhibitor of signal peptide peptidase; inhibits p-Prl signal peptide processing. | [Biological Activity]
(Z-LL)2 Ketone is a selective inhibitor of signal peptide peptidase (SPP) th at inhibits processing of the p-Prl signal peptide (IC50 = ~ 50 nM) without affecting the activities of signal peptidases and other proteases such as lysosomal cathepsins and proteasomes.''(Z-LL)2 Ketone serves as an inverse γ-secretase modulator (iGSM) by changing processivity of γ-secretase cleavage. |
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| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Enzo Biochem Inc
|
| Tel: |
Enzo Biochem Inc. 13797054060 |
| Website: |
www.enzo.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|