| Identification | Back Directory | [Name]
FSL-1 lipoprotein, synthetic | [CAS]
322455-70-9 | [Synonyms]
(R)-FSL-1
FSL-1 >=80% (HPLC)
FSL-1 lipoprotein, synthetic | [Molecular Formula]
C84H140N14O18S | [MDL Number]
MFCD29049541 | [MOL File]
322455-70-9.mol | [Molecular Weight]
1666.16 |
| Chemical Properties | Back Directory | [Boiling point ]
1659.8±65.0 °C(Predicted) | [density ]
1?+-.0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
powder | [pka]
3.46±0.10(Predicted) | [color ]
Colorless | [Water Solubility ]
H2O: soluble |
| Hazard Information | Back Directory | [Uses]
FSL-1, a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist, enhances resistance to experimental HSV-2 infection[1][2]. | [Biological Activity]
FSL-1 (Pam2CGDPKHPKSF) is a synthetic lipoprotein th at acts as a Toll-like Receptor 2/6 (TLR2/6) agonist and activator of nuclear transcription factor NF-KB. FSL-1 is based on the N-terminal part of the 44-kDa lipoprotein LP44 of Mycoplasma salivarium. FSL-1 showed higher stimulatory activity than MALP-2 in its ability to induce TNF-α production in macrophages and NF-KB in TLR2/TLR6 transfected HEK293 cells.''FSL-1 is a bacterial-derived toll-like receptor 2/6 agonist. It is capable of increasing resistance to herpes simplex virus type 2 (HSV-2) infection. | [IC 50]
TLR2; TLR6 | [storage]
Store at -20°C | [References]
[1] William A Rose 2nd, et al. FSL-1, a bacterial-derived toll-like receptor 2/6 agonist, enhances resistance to experimental HSV-2 infection. Virol J. 2009 Nov 10;6:195. DOI:10.1186/1743-422X-6-195
[2] Rasheed Ahmad, et al. FSL-1 induces MMP-9 production through TLR-2 and NF-κB /AP-1 signaling pathways in monocytic THP-1 cells. Cell Physiol Biochem. 2014;34(3):929-42. DOI:10.1159/000366310 |
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BOC Sciences
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| Tel: |
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https://www.bocsci.com |
| Company Name: |
Energy Chemical
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021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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