| Identification | Back Directory | [Name]
Pyrazinecarboxamide, 3-amino(7CI,9CI) | [CAS]
32587-10-3 | [Synonyms]
32587-10-3
Pyrazinecarboxamide, 3-amino- (7CI,9CI)
3-Amino-pyrazine-2-carboxylic acid amide | [Molecular Formula]
C5H6N4O | [MDL Number]
MFCD03407446 | [MOL File]
32587-10-3.mol | [Molecular Weight]
138.127 |
| Chemical Properties | Back Directory | [Melting point ]
239.3 °C | [Boiling point ]
375.8±37.0 °C(Predicted) | [density ]
1.426±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C(protect from light) | [form ]
Solid | [pka]
13.68±0.50(Predicted) | [Appearance]
Light brown to brown Solid | [CAS DataBase Reference]
32587-10-3 |
| Hazard Information | Back Directory | [Synthesis Reference(s)]
Journal of the American Chemical Society, 81, p. 2472, 1959 DOI: 10.1021/ja01519a047 | [Synthesis]
Example 2 Synthesis of 3-aminopyrazine-2-carboxamide (Intermediate 1): methyl 3-aminopyrazine-2-carboxylate (5.0 g, 33 mmol) was dissolved in concentrated ammonium hydroxide solution (30 mL), heated to 60°C and kept for 3 hours. After completion of the reaction, the mixture was cooled to room temperature and the precipitated solid was collected by filtration. The solid was washed well with water and ether in turn to afford the title compound 3-aminopyrazine-2-carboxamide as a brown solid (3.7 g, 82% yield). The product was characterized by 1H NMR (500 MHz, DMSO-d6): δ 8.19 (d, J = 2.4 Hz, 1H), 8.07 (br s, 2H), 7.80 (d, J = 2.4 Hz, 1H), 7.59 (br s, 2H). Mass spectrum (ES+): m/z 139 ([M + H]+). | [References]
[1] Journal of Heterocyclic Chemistry, 2012, vol. 49, # 4, p. 865 - 872
[2] Patent: CN106699759, 2017, A. Location in patent: Paragraph 0050; 0051; 0052
[3] Patent: US2007/259876, 2007, A1. Location in patent: Page/Page column 17
[4] Journal of the American Chemical Society, 1945, vol. 67, p. 1711
[5] Patent: US2011/118269, 2011, A1. Location in patent: Page/Page column 13 |
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