| Identification | Back Directory | [Name]
4-phenylnaphthalen-1-ylboronic acid | [CAS]
372521-91-0 | [Synonyms]
(4-Phenylnaphthalen-1-yl)
4-phenylnaphthalen-1-ylboronic acid
1-(4-phenylnaphthalene)boronic acid
4-Phenylnaphthalene-1-boronic acid97
4-phenyl(napthalene-1-yl)boronic acid
(1-Phenylnaphthalen-4-yl)boronic acid
4-Phenylnaphthalene-1-boronicacid,98%
4-Phenylnaphthalene-1-boronic acid, 98%
B-(4-phenyl-1-naphthalenyl)boronic acid
Boronic acid, B-(4-phery-1-naphthaleny)-
Boronic acid,B-(4-phenyl-1-naphthalenyl)-
(4-(4-Phenylnaphthalen-1-yl)phenyl)boronic acid
4-Phenylnaphthalene-1-boronicAcid(containsvaryingamountsofAnhydride)>
4-Phenylnaphthalene-1-boronic Acid (contains varying amounts of Anhydride) | [Molecular Formula]
C16H13BO2 | [MDL Number]
MFCD08669639 | [MOL File]
372521-91-0.mol | [Molecular Weight]
248.084 |
| Chemical Properties | Back Directory | [Boiling point ]
449.4±48.0 °C(Predicted) | [density ]
1.23 | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [form ]
Solid | [pka]
8.54±0.30(Predicted) | [color ]
White to Almost white | [InChI]
InChI=1S/C16H13BO2/c18-17(19)16-11-10-13(12-6-2-1-3-7-12)14-8-4-5-9-15(14)16/h1-11,18-19H | [InChIKey]
BSKLSKWOKGVQHF-UHFFFAOYSA-N | [SMILES]
B(C1=C2C(C=CC=C2)=C(C2=CC=CC=C2)C=C1)(O)O | [CAS DataBase Reference]
372521-91-0 |
| Hazard Information | Back Directory | [Synthesis]
Example 1: Preparation of compound C-12
Preparation of Compound 2 [(4-phenylnaphthalen-1-yl)boronic acid]
[1081] 1-bromo-4-phenylnaphthalene (Compound 1) (50 g, 176 mmol) was dissolved in anhydrous tetrahydrofuran (THF) (1 L) in a flask. The mixture was stirred at -78°C and n-butyllithium (n-BuLi) (2.5 M in hexane, 132 mL) was added slowly and dropwise. The reaction mixture was stirred at room temperature for 1 hour. Subsequently, the reaction mixture was cooled to -78°C and triisopropyl borate (61 mL, 264 mmol) was added slowly and dropwise. The reaction mixture was then stirred at room temperature for 3 hours. After completion of the reaction, extraction was carried out with ethyl acetate. The organic layer obtained from the extraction was dried with magnesium sulfate (MgSO?) and solidified by hexane to give compound 2 (30 g, 68% yield). | [References]
[1] Patent: WO2014/88290, 2014, A1. Location in patent: Paragraph 105; 106; 107; 108 |
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