| Identification | Back Directory | [Name]
(2S)-1-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-[(4-pyridinylmethyl)amino]-1-butanonehydrochloride | [CAS]
372523-75-6 | [Synonyms]
TCS OX2 29
TCS-OX2-29, CID 10408514
(2S)-1-(6,7-DIMETHOXY-3,4-DIHYDRO-1H-ISOQUINOLIN-2-YL)-3,3-DIMETHYL-2-(PYRIDIN-4-YLMETHYLAMINO)BUTAN-1-ONE
1-Butanone, 1-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-[(4-pyridinylmethyl)amino]-, (2S)-
(2S)-1-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-[(4-pyridinylmethyl)amino]-1-butanonehydrochloride | [Molecular Formula]
C23H31N3O3 | [MOL File]
372523-75-6.mol | [Molecular Weight]
397.51 |
| Chemical Properties | Back Directory | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [solubility ]
DMSO : 25 mg/mL (62.89 mM; Need ultrasonic)Ethanol : 25 mg/mL (62.89 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble) | [form ]
Powder | [color ]
White to off-white | [Water Solubility ]
H2O: ≥2.0mg/mL, clear |
| Hazard Information | Back Directory | [Uses]
TCS OX2 29 is a potent and selective orexin-2 receptor (OX2) antagonist. | [Biological Activity]
TCS OX2 29 or TCS-OX2-29 is a potent and selective orexin 2 receptor (Ox2ROx2-ROx-2-R) antagonist (IC50 = 40 nM/Ox2R>10 μM/Ox1R) with little potency toward 50 other receptorsion channelsand transporters tested (<30% inhibition at 10 μM). TCS OX2 29 is widely used for elucidating various physiological functions mediated by Ox2R both in cultures and in mice and rats in vivo. | [in vivo]
TCS-OX2-29 (5-10 mg/kg; intraperitoneal injection; adult male NMRI mice) treatment suppresses conditioned place preference (CPP) acquisition and expression in both na ve and dependent mice significantly[2]. | Animal Model: | 440 adult male NMRI mice (25-30 g)[2] | | Dosage: | 5 mg/kg and 10 mg/kg | | Administration: | Intraperitoneal injection (Pharmacokinetic study) | | Result: | Suppressed conditioned place preference (CPP) acquisition and expression in both na?ve and dependent mice significantly.
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| [IC 50]
OX2 Receptor | [storage]
Store at -20°C |
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