| Identification | Back Directory | [Name]
Bertilimumab | [CAS]
375348-49-5 | [Synonyms]
Cat-213
Bertilimumab
Bertilimumab [inn]
Research Grade Bertilimumab
Human anti-eotaxin 1 monoclonal antibody
Immunoglobulin G4, anti-(human eotaxin 1) (human monoclonal cat-213 gamma 4-chain), disulfide with human monoclonal cat-213 kappachain, dimer |
| Hazard Information | Back Directory | [Uses]
Bertilimumab (CAT 213; iCo-008) is a human monoclonal antibody targeting eotaxin-1 (CCL11). Bertilimumab has the potential for allergic disorders research[1]. | [in vivo]
Bertilimumab (CAT 213) (0.01-10 mg/kg) administered i.v. 30 min before i.po. injection of human eotaxin1 (1 μg) causes a significant dose-dependent inhibition of eosinophil recruitment in IL-5-treated, ovalbumin-sensitized mice. Bertilimumab also significantly inhibits neutrophil and mononuclear cell influx into the air pouch, which resulted in a dose-related inhibition of total cell influx[1]. | Animal Model: | Female BALB/c mice (17-21 g) injected human eotaxin1[1]. | | Dosage: | 0.01 mg/kg, 0.1 mg/kg, 1 mg/kg, 10 mg/kg | | Administration: |
i.v; once | | Result: | Caused a significant dose-dependent inhibition of eosinophil recruitment in IL-5-treated, ovalbumin-sensitized mice. |
| [References]
[1] Sarah Main, et al. A potent human anti-eotaxin1 antibody, CAT-213: isolation by phage display and in vitro and in vivo efficacy. J Pharmacol Exp Ther. 2006 Dec;319(3):1395-404. DOI:10.1124/jpet.106.110734 |
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