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ChemicalBook--->CAS DataBase List--->409086-68-6

409086-68-6

409086-68-6 Structure

409086-68-6 Structure
IdentificationBack Directory
[Name]

PyridiniuM, 2-[[3-ethyl-5-(3-Methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]Methyl]-1-Methyl-, chloride (1:1)
[CAS]

409086-68-6
[Synonyms]

YM-01
YM-01 (YM-1)
YM-01 (YM-1), allosteric Hsp70 modulator
2-[[3-Ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-1-methyl-pyridinium chloride
2-((3-Ethyl-5-(3-methylbenzo[d]thiazol-2(3H)-ylidene)-4-oxothiazolidin-2-ylidene)methyl)-1-methylpyridin-1-ium chloride
PyridiniuM, 2-[[3-ethyl-5-(3-Methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]Methyl]-1-Methyl-, chloride (1
PyridiniuM, 2-[[3-ethyl-5-(3-Methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]Methyl]-1-Methyl-, chloride (1:1)
[Molecular Formula]

C20H20ClN3OS2
[MDL Number]

MFCD28009511
[MOL File]

409086-68-6.mol
[Molecular Weight]

417.97
Chemical PropertiesBack Directory
[storage temp. ]

2-8°C
[solubility ]

H2O: soluble2mg/mL, clear (warmed)
[form ]

powder
[color ]

orange to dark red
[Water Solubility ]

H2O: 2mg/mL, clear (warmed)
Safety DataBack Directory
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

YM-1 has been used as a Hsp70 (heat shock protein) inhibitor in cell viability assay.
[Biochem/physiol Actions]

YM-1 modulates Hsp70 activity by binding to the nucleotide-binding domain of ADP- but not ATP-bound Hsp70, stabilizing Hsp70 in its ADP-bound conformation. The ADP-bound state has tight affinity for its substrates, promoting their ubiquitination and degradation, and a greatly reduced off rate compared to the ATP-bound state. YM-1 appears to behave in a similar manner to Hip, a Hsp70 co-chaperone that stabilizes Hsp70 in its ADP-bound conformation which favors degradation of misfolded substrates such as those involved in various neurodegenerative diseases. YM-1 also has anticancer activity, which could be due to enhanced ubiquitination and clearance of Akt, a major survival kinase. In studies with multiple cancer lines, YM-1 was found to selectively target cancer cells over normal cells and to overcome tamoxifen resistance in a tamoxifen-resistant MCF7 cell model. YM-1 had greater efficacy and cytosolic localization than the closely related MKT-077 (M5449).
[in vivo]

YM-1 (1 mM; oral administration, for 7 days) rescues polyQ toxicity in Drosophila by activating Hsp70[1].

Animal Model:UAS-hAR52Q flies with polyQ AR-induced dihydrotestosterone (DHT) phenotype[1]
Dosage:1 mM
Administration:Oral administration; 1 mM, for 7 days
Result:Weakened the DHT-dependent eye degeneration phenotype and rescued DHT-dependent pupal toxicity of the polyQ AR.
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