| Identification | Back Directory | [Name]
5-ANDROSTENE-3B,16A,17B-TRIOL | [CAS]
4150-30-5 | [Synonyms]
5-Androstenetriol
5-Androstene-3,16,17-triol
5-ANDROSTENE-3B,16A,17B-TRIOL
Androst-5-ene-3β,16α,17β-triol
5-Androstene-3B,16ALPHA,17B-triol
3β,16α,17β-Trihydroxy-5-androstene
5-androstene-3beta,16alpha,17beta-trihydroxy-5-androstene
(8R,9S,10R,13S,14S)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,16,17-triol | [Molecular Formula]
C19H30O3 | [MDL Number]
MFCD00199375 | [MOL File]
4150-30-5.mol | [Molecular Weight]
306.44 |
| Chemical Properties | Back Directory | [Melting point ]
261-264 °C | [Boiling point ]
449.8±45.0 °C(Predicted) | [density ]
1.19±0.1 g/cm3(Predicted) | [solubility ]
DMSO: soluble; Ethanol: soluble | [form ]
A solid | [pka]
14.52±0.70(Predicted) |
| Hazard Information | Back Directory | [Uses]
5-Androstenetriol is a systemic radiation protector that can boost the host's immunity, leading to increased resistance to infections. 5-Androstenetriol can raise levels of IL-2, IL-3, and IFN, while countering the immunosuppressive effects of Hydrocortisone (HY-N0583)[1][2]. | [Definition]
ChEBI: 5-Androstenetriol is a 3-hydroxy steroid. It has a role as an androgen. | [IC 50]
IL-2; IL-3 | [References]
[1] R M Loria, et al. Androstenetriol and androstenediol. Protection against lethal radiation and restoration of immunity after radiation injury. Ann N Y Acad Sci. 2000:917:860-7. DOI:10.1111/j.1749-6632.2000.tb05452.x
[2] Mark H Whitnall, et al. Molecular specificity of 5-androstenediol as a systemic radioprotectant in mice. Immunopharmacol Immunotoxicol. 2005;27(1):15-32. DOI:10.1081/iph-51289 |
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